Does Spironolactone Cause Weight Gain

Weight Fluctuations


Conditions like high blood pressure and heart failure are primarily treated with spironolactone. Still, it has also gained popularity in recent years as a treatment for hormonal acne and excessive hair growth.

However, some people have expressed concern that spironolactone may lead to unwanted weight gain or fluctuations. In this article, we will dive into the truth behind these claims and separate fact from fiction.

What is Spironolactone

Spironolactone is a prescription medication that is used to treat a variety of conditions, including high blood pressure, heart failure, and hirsutism (excessive hair growth on the face and body in women). It is also sometimes used to treat acne and hair loss.

Spironolactone is a potassium-sparing diuretic, meaning it helps in the removal of excess fluid from the body while preserving potassium levels. It operates by blocking the effects of aldosterone, a hormone responsible for the body’s retention of sodium and water.

It is a diuretic, which means it assists the body in eliminating excess fluid through increased urine production. As a result, some individuals may experience initial weight loss due to reduced fluid retention. However, it’s important to note that this initial weight loss is temporary and not indicative of long-term weight management.

spironolactone and weight gain

Debunking the Myth: Does Spironolactone Cause Weight Gain?

Limited scientific evidence supports the claim that spironolactone directly causes weight gain despite rumors and anecdotal reports. Several inconclusive studies have explored the relationship between spironolactone and weight changes.

Some studies have shown a slight increase in body weight among individuals taking spironolactone, while others have found no significant difference. The weight changes observed in these studies were generally modest and not clinically significant.

What are the Side Effects of Spironolactone?

Spironolactone can cause a variety of side effects, including:

  • Dizziness
  • Weakness
  • Headache
  • Nausea
  • Diarrhea
  • Breast tenderness
  • Menstrual irregularities
  • Decreased sex drive
  • Kidney problems

Factors That Contribute to Weight Gain While on Spironolactone

While spironolactone may not be a direct cause of weight gain, several factors can contribute to weight fluctuations in individuals taking this medication.

Hormonal changes, such as those seen in conditions like polycystic ovary syndrome (PCOS), can affect metabolism and lead to weight gain. Additionally, spironolactone can cause changes in potassium levels, which may impact water balance in the body and result in weight fluctuations.

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How Do You Manage Weight Gain While Taking Spironolactone?

If you are concerned about it while taking spironolactone, there are a few things you can do to manage it:

  • Consume a generous amount of fruits, vegetables, and whole grains. Opt for lean protein sources like beans, chicken, and fish. Restrict your intake of processed foods, sugary beverages, and unhealthy fats.
  • Strive for a minimum of 30 minutes of moderate-intensity exercise on most days of the week. Walking, swimming, and yoga all constitute excellent choices for individuals on spironolactone.
  • Talk to your doctor: If you are experiencing weight gain while taking spironolactone, talk to your doctor.

Alternative Treatment Options

If you’re still concerned about the potential side effects of spironolactone or if it’s not the right treatment option for you, it’s important to discuss alternative options with your healthcare provider.

Depending on your specific condition, there may be other medications or treatment approaches available that can address your concerns without the potential for weight fluctuations.


Weight gain is not a common side effect of spironolactone. However, it is possible to experience weight gain while taking spironolactone, especially if you are also experiencing fluid retention.

With adequate sleep, you can effectively manage your weight while on spironolactone.

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